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The trypanosomatidae family includes the genera trypanosoma and leishmania, protozoan parasites displaying complex digenetic life cycles requiring a vertebrate host and an insect vector. Trypanosoma brucei gambiense, trypanosoma cruzi, and leishmania spp. Are important human pathogens causing human african trypanosomiasis (hat or sleeping sickness), chagas’. Protozoan pathogens such as plasmodium, leishmania, trypanosoma and entamoeba are responsible for several of the most widespread and lethal human diseases.