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A red blood cell will swell and undergo hemolysis (burst) when placed in a hypotonic solution. When placed in a hypertonic solution, a red blood cell will lose water and undergo crenation (shrivel). In crenation, the cells shrink and their shapes become distorted, often with a ruffled or scalloped edge. Red blood cells are prone to undergoing crenation as either a response to ionic changes in the blood or abnormalities in the cell membrane, disrupting the cell’s ability to maintain an isotonic state.